Fig. 5

TAK242 suppresses the TLR4/MAPK/Nrf2 pathway and autophagy in tBHP-induced H9C2 cells. A H9C2 cells were pretreated with TAK242 (10 μM) for 1 h and then acted with tBHP (150 μM) for 4 h, the cell viability was detected by MTT assay. B The effect of TAK242 on the level of TLR4, p-P38, p-ERK1/2, p-JNK. C The statistics of protein levels of (B). D The effect of TAK242 on the level of Nrf2, Keap1, HO-1, NQO1. E The statistics of protein levels of (D). F The effect of TAK242 on the level of LC3B, P62. G The statistics of protein levels of (F). ^#P < 0.05, ^##P < 0.01, ^###P < 0.005 vs Control; ^*P < 0.05, ^**P < 0.01, ^***P < 0.005 vs tBHP (or DMSO)